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目的探讨多囊卵巢综合征(PCOS)并发代谢综合征(MS)的育龄妇女在诱导排卵前予口服避孕药及比格列酮行预处理的临床意义。方法回顾性分析2010年1月至2012年12月于广东医学院附属医院生殖医学中心确诊PCOS的育龄妇女383例,均有排卵稀发或排卵障碍。分为对照组(无并发MS者,直接诱导排卵治疗)106例;观察组A(并发MS者,直接诱导排卵治疗)52例;观察组B(并发MS者,诱导排卵治疗前行预处理)225例。比较三组患者的优势卵泡个数、子宫内膜厚度及妊娠成功率。结果观察组B和对照组临床妊娠率均高于观察组A,差异有统计学意义(P<0.05);观察组B的临床妊娠与对照组相似,差异无统计学意义(P>0.05);三组患者诱导排卵的优势卵泡个数、子宫内膜厚度比较差异无统计学意义(P>0.05)。结论 PCOS并发MS育龄妇女诱导排卵前行预处理具有临床意义。
Objective To investigate the clinical significance of preterm ovulation induction and oral administration of pioglitazone in women of childbearing age with polycystic ovary syndrome (PCOS) complicated with metabolic syndrome (MS). Methods A retrospective analysis of 383 women of childbearing age who had been diagnosed with PCOS at the Reproductive Medicine Center of Guangdong Medical College from January 2010 to December 2012 was made with either ovulation or hair loss or ovulation disorder. Were divided into control group (no concurrent MS, direct induction of ovulation treatment) 106 cases; observation group A (with MS, direct induction of ovulation treatment) 52 cases; observation group B (concurrent MS, induced ovulation induction treatment before the pretreatment) 225 cases. The number of dominant follicles, the thickness of endometrium and the success rate of pregnancy in three groups were compared. Results The clinical pregnancy rates in observation group B and control group were significantly higher than those in observation group A (P <0.05). The clinical pregnancy in observation group B was similar to that in control group (P> 0.05). The number of dominant follicles and endometrial thickness induced by ovulation in three groups had no significant difference (P> 0.05). Conclusions PCOS with MS in women of reproductive age induces ovulation pretreatment has clinical significance.