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目的分析肝脏激酶B1(LKB1)在冠心病中的临床表达及意义。方法选取200例冠心病患者(急性心肌梗死100例,冠状动脉狭窄100例)和200例健康体检者作为研究对象,均接受冠状动脉造影检查,术前30 min抽取4 ml外周血,LKB1血清浓度用酶联免疫吸附法(ELISA)进行测定,并比较各组血清LKB1水平以及低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯水平。结果急性心肌梗死患者LKB1水平为(3.03±1.05)ng/ml,冠状动脉狭窄患者为(3.31±0.78)ng/ml,健康体检者为(4.33±1.69)ng/ml,冠心病患者LKB1水平低于健康体检者,差异有统计学意义(P<0.05)。急性心肌梗死患者LDL-C、HDL-C、甘油三酯水平分别为(2.79±0.84)、(1.48±0.34)、(1.74±0.77)mmol/L,冠状动脉狭窄患者分别为(2.76±0.81)、(1.50±0.33)、(1.58±0.70)mmol/L,健康体检者分别为(2.63±0.79)、(1.52±0.85)、(1.60±0.82)mmol/L。冠心病患者LDL-C、HDL-C、甘油三酯水平与健康体检者比较,差异无统计学意义(P>0.05)。结论冠心病患者LKB1水平较健康者低,在冠心病检测中具重要意义。
Objective To analyze the clinical significance and expression of liver kinase B1 (LKB1) in coronary heart disease. Methods 200 coronary heart disease patients (100 cases of acute myocardial infarction, 100 cases of coronary artery stenosis) and 200 healthy subjects were selected as subjects, all underwent coronary angiography, 30 ml before surgery to take 4 ml of peripheral blood, LKB1 serum concentration The levels of serum LKB1, LDL-C, HDL-C and triglyceride were compared by enzyme-linked immunosorbent assay (ELISA). Results The levels of LKB1 in acute myocardial infarction patients were (3.03 ± 1.05) ng / ml, (3.31 ± 0.78) ng / ml in patients with coronary artery stenosis, (4.33 ± 1.69) ng / ml in healthy subjects and low in LKB1 in patients with coronary heart disease In healthy subjects, the difference was statistically significant (P <0.05). The levels of LDL-C, HDL-C and triglyceride were (2.79 ± 0.84), (1.48 ± 0.34) and (1.74 ± 0.77) mmol / L in patients with acute myocardial infarction and 2.76 ± 0.81 in patients with coronary artery stenosis , (1.50 ± 0.33) and (1.58 ± 0.70) mmol / L, respectively, and healthy subjects were (2.63 ± 0.79), (1.52 ± 0.85) and (1.60 ± 0.82) mmol / L respectively. The levels of LDL-C, HDL-C and triglyceride in CHD patients were not significantly different from those in healthy subjects (P> 0.05). Conclusions LKB1 levels in patients with coronary heart disease are lower than those in healthy people and have important significance in the detection of coronary heart disease.