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目的 研究分泌性中耳炎时咽鼓管表面活性物质的变化 ,为分泌性中耳炎的治疗提供客观依据。方法 将灭活的肺炎链球菌悬液注入豚鼠鼓室 ,制成豚鼠分泌性中耳炎动物模型 ,然后取出正常组和模型组豚鼠咽鼓管 ,测定及分析两组豚鼠咽鼓管表面活性物质。结果 对照组与模型组豚鼠咽鼓管表面活性物质主要生化成分的差别有显著性意义 ,模型组咽鼓管表面活性物质主要生化成分磷脂酰胆碱 (PC)和磷脂酰乙醇胺 (PE)明显减少(均P<0.001) ,其活性也明显下降 (P<0.001)。 结论 分泌性中耳炎时咽鼓管表面活性物质主要成分的减少和活性下降 ,可能在分泌性中耳炎的发生与发展中有重要作用
Objective To study the changes of eustachian tube surface active substances in secretory otitis media and provide an objective basis for the treatment of secretory otitis media. Methods Inactivated guinea pig eustachian tube suspension was injected into guinea pig tympanic cavity to make secreted otitis media in guinea pigs. The eustachian tube of guinea pigs in normal group and model group were removed, and the eustachian tube surface active substances in guinea pigs were measured and analyzed. Results The main biochemical components of the eustachian tube of guinea pigs in the control group and the model group were significantly different. The main biochemical components of the eustachian tube surface active substance, phosphatidylcholine (PC) and phosphatidylethanolamine (PE), were significantly decreased (All P <0.001), and their activities were significantly decreased (P <0.001). Conclusions The decrease of the main components of the eustachian tube superficial otitis media and the decrease of its activity may play an important role in the occurrence and development of secretory otitis media