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目的观察坤泰方治疗多囊卵巢综合征的临床疗效。方法将105例多囊卵巢综合征患者随机分为治疗组(53例)与对照组(52例)。治疗组予坤泰方口服治疗,对照组予炔雌醇环丙孕酮口服治疗。两组疗程均为3个月,观察临床疗效,并比较治疗前后生殖内分泌相关指标(促卵泡生成素、黄体生成激素、雌二醇、泌乳素、睾酮、性激素结合蛋白及瘦素)、体质量指数、腰臀比的变化情况;同时随访3个月,观察排卵率与妊娠率的情况。结果①共有97例患者完成临床观察,治疗组48例、对照组49例。②治疗组、对照组总有效率分别为89.6%、73.5%;组间临床疗效比较,差异有统计学意义(P<0.05)。③治疗前后组内比较,两组FSH、E2、PRL水平差异无统计学意义(P>0.05)。治疗组LH、T、SHBG、Leptin水平差异有统计学意义(P<0.05);对照组LH、T水平差异有统计学意义(P<0.05),而SHBG、Leptin水平差异无统计学意义(P>0.05);组间治疗后比较,FSH、E2、PRL水平差异无统计学意义(P>0.05);SHBG、Leptin水平差异均有统计学意义,治疗组优于对照组(P<0.05);T、LH水平差异有统计学意义,对照组优于治疗组(P<0.05)。④治疗前后组内比较,治疗组BMI指数差异有统计学意义(P<0.05),WHR指数差异无统计学意义(P>0.05);对照组BMI、WHR指数差异均无统计学意义(P>0.05)。组间治疗后比较,BMI指数差异有统计学意义(P<0.05);而WHR指数差异无统计学意义(P>0.05)。⑤治疗后随访3个月期间,治疗组排卵率、妊娠率分别为35.4%、16.7%;对照组排卵率、妊娠率分别为6.1%、0%。组间排卵率与妊娠率比较,差异有统计学意义(P<0.05)。结论坤泰方治疗多囊卵巢综合征可改善患者临床症状,调节相关生殖内分泌激素水平,提高排卵率及妊娠率。
Objective To observe the clinical efficacy of Kun Tai Fang in the treatment of polycystic ovary syndrome. Methods 105 patients with PCOS were randomly divided into treatment group (n = 53) and control group (n = 52). The treatment group was given KunTaiFang oral treatment, the control group was given ethinyl estradiol cyproterone oral treatment. The two courses of treatment were 3 months, the clinical efficacy was observed, and compared before and after treatment of reproductive and endocrine-related indicators (follicle stimulating hormone, luteinizing hormone, estradiol, prolactin, testosterone, sex hormone binding protein and leptin), body mass Index, waist-hip ratio changes; while 3-month follow-up, observe the ovulation rate and pregnancy rate. Results ① A total of 97 patients completed clinical observation, 48 cases in the treatment group and 49 cases in the control group. ② The total effective rates of the treatment group and the control group were 89.6% and 73.5%, respectively. There was significant difference between the two groups in clinical efficacy (P <0.05). ③ Before and after treatment, there was no significant difference in FSH, E2 and PRL between the two groups (P> 0.05). The levels of LH, T, SHBG and Leptin in the treatment group were significantly different (P <0.05). The levels of LH and T in the control group were significantly different (P <0.05), while there were no significant differences in the levels of SHBG and Leptin (P> 0.05). There was no significant difference in the levels of FSH, E2 and PRL between the two groups after treatment (P> 0.05). The levels of SHBG and Leptin in the treatment group were significantly higher than those in the control group (P <0.05). T, LH levels were significantly different in the control group than in the treatment group (P <0.05). (4) There were significant differences in BMI index between the two groups before and after treatment (P <0.05), no significant difference in WHR index between the two groups (P> 0.05). There was no significant difference in BMI and WHR between the two groups (P> 0.05). There were significant differences in BMI index between the two groups after treatment (P <0.05), but there was no significant difference in WHR index between the two groups (P> 0.05). ⑤ After 3 months of follow-up, the ovulation rate and pregnancy rate in the treatment group were 35.4% and 16.7%, respectively. The ovulation rate and pregnancy rate in the control group were 6.1% and 0% respectively. The ovulation rate and pregnancy rate between the groups, the difference was statistically significant (P <0.05). Conclusion Kun Tai Fang treatment of polycystic ovary syndrome can improve clinical symptoms, regulate the level of reproductive endocrine hormone, improve ovulation rate and pregnancy rate.