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数十年来,消化性溃疡的发病率和危害性不断下降,因溃疡病而做手术治疗者也相应减少.这些情况甚至出现在甲氰咪胍问世之前.更重要的是,以年龄、性别统计的消化性溃疡的死亡率也在下降.例如,1930～1976年,50岁以上男性十二指肠溃疡患者的死亡率,在苏格兰由154人/百万人降为24人/百万人,在英格兰由109人/百万人降为16人/百万人.在美国由1921年的40人/百万人降为1976年的7人/百万人.女性消化性溃疡患者的死亡率也有相似下降的报道.
For decades, the incidence and the harmfulness of peptic ulcers have been declining, and the number of patients who have undergone surgical treatment for ulcer disease has also decreased, even before the advent of cimetidine. More importantly, by age and sex Of the mortality rate of peptic ulcer is also declining.For example, from 1930 to 1976, the mortality rate of male patients with duodenal ulcers over the age of 50 in Scotland from 154 per million to 24 per million, In England, from 109 to 16 people / million and in the United States from 40 to one million in 1921 to 7 in 1976. Mortality rate in women with peptic ulcer There are also reports of similar drops.