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辽宁省鼠疫自然疫源地实施以灭鼠为主的综合防制措施，经４０余年的努力，自然疫源地已被消除．主要依据是：４０年未检出鼠疫菌，２１年未检出血清阳性材料；黄鼠密度降至０．０５只／公顷以下，９５％地块为无鼠区，并连续保持１５年；黄鼠体染蚤率下降至３０％或以下，体蚤指数降至２以下，室内游离蚤指数接近于０．同时疫区生态系发生了根本性改变，林地面积占疫源地总面积三分之一，草原面积缩小，黄鼠最适生境遭受破坏．
Liaoning Province, plague natural foci to implement a comprehensive anti-rat control measures, after 40 years of hard work, natural foci have been eliminated. The main basis is: 40 years did not detect Yersinia pestis, 21 years did not detect serum-positive material; rat density decreased to 0.05 / hectare, 95% of the land area for no mouse, and continued to maintain 15 years; yellow The rate of flea infection decreased to 30% or less, the body flea index dropped below 2, and the indoor flea index was close to zero. At the same time, the epidemic area ecosystem has undergone fundamental changes, with the area of forestland accounting for one third of the total area of epidemic areas, and the grassland area has been reduced, and the optimum habitat for the gopher has been destroyed.