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目的 :探讨巴曲抗栓酶对老年腔隙性脑梗死病人甲襞微循环及血液流变学的影响。方法 :经CT或MRI确诊的老年腔隙性脑梗死病人 4 8例 ,给巴曲抗栓酶治疗 ,d 1给 10BU ,以后 5BU ,qod ,ivgtt ,总剂量 2 0BU ,治疗前后分别进行甲襞微循环及血液流变学检测。结果 :腔隙性脑梗死病人均有明显微循环及血液流变学异常 ,治疗后异常指标得到改善 ,但管攀模糊、微静脉口径、血流速度、红细胞聚集及微血栓数等指标与正常对照组差异无显著意义 (P >0 .0 5) ,临床总有效率 96 %。结论 :巴曲抗栓酶可改善老年腔隙性脑梗死病人的微循环及血液流变学异常 ,可起到“微血管疏通剂”的作用。
Objective: To investigate the effect of batroxobin on nailfold microcirculation and hemorheology in elderly patients with lacunar infarction. Methods: 48 elderly patients with lacunar infarction diagnosed by CT or MRI were treated with batroxobin, d 1 was given to 10BU, then 5BU, qod, ivgtt and total dose was 20 BU. Microcirculation and hemorheology testing. Results: The patients with lacunar infarction had obvious microcirculation and abnormal hemorheology, and the abnormal indexes were improved after treatment. However, the indexes of microcirculation, diameter of arterioles, blood flow velocity, erythrocyte aggregation and microthrombus were normal to normal There was no significant difference in the control group (P> 0.05), the total effective rate was 96%. Conclusion: Batroxobin can improve the microcirculation and hemorheology of elderly patients with lacunar infarction and play the role of “microvascular clearing agent”.