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目的探讨枸橼酸西地那非(商品名为万艾可)在治疗顽固性、心因性勃起功能障碍中的地位。方法2002年3月至2005年1月我院男科门诊共收治54例顽固性、心因性勃起功能障碍患者,随机均分为治疗组和对照组。治疗组患者均给予枸橼酸西地那非100mg隔天连续口服,10d为1个疗程,服药时间不超过2个疗程;对照组给予六味地黄丸口服,10d为1个疗程,服药时间不超过20d。两组患者均在疗程结束后随访3个月,患者治疗前和治疗结束后1周、3个月进行国际勃起功能指数(IIEF-5)评分,并进行夫妻间性生活满意度的简单测评。结果治疗组患者治疗前、后IIEF-5积分的差异有显著性(P<0.01),对照组治疗前、后IIEF-5积分的差异无显著性(P>0.05);治疗后3个月,治疗组IIEF-5积分与对照组的差异有显著性(P<0.01)。治疗前、后治疗组夫妇双方性生活满意度的差异有显著性(P<0.01),而对照组性生活满意度的差异无显著性(P>0.05)。结论连续口服枸橼酸西地那非治疗顽固性、心因性勃起功能障碍有效,值得临床进一步探讨。
Objective To investigate the status of sildenafil citrate (brand name Viagra) in the treatment of intractable, psychogenic erectile dysfunction. Methods From March 2002 to January 2005, 54 male patients with intractable and psychogenic erectile dysfunction were admitted to our hospital, and were randomly divided into treatment group and control group. Patients in the treatment group were given continuous oral administration of sildenafil citrate 100mg on the next day, 10 days for a course of treatment, taking no more than two courses of treatment; the control group given Liuweidihuangwan oral, 10d for a course of treatment, taking no more than 20d. The two groups were followed up for 3 months after the end of treatment, before the treatment and after 1 week and 3 months after treatment, the IIEF-5 score and simple evaluation of sexual life satisfaction between husband and wife. Results The difference of IIEF-5 scores before and after treatment in treatment group was significant (P <0.01), there was no significant difference in IIEF-5 score before and after treatment in control group (P> 0.05). At 3 months after treatment, There was a significant difference between the treatment group and the control group (P <0.01). There were significant differences in sexual satisfaction between the two groups before and after treatment (P <0.01), but no significant differences in sex life satisfaction between the two groups (P> 0.05). Conclusion Continuous oral sildenafil citrate treatment of intractable, erectile dysfunction, effective, worth further clinical study.