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应用气相－电子捕获法（ＧＣＥＣＤ）对１６名健康志愿受试者（青年组８名，老年组８名）单剂量舌下含服硝酸甘油片剂０．５ｍｇ后的药代动力学及药效学进行了研究。于用药前和用药后２、４、６、７、８、１０、１５、２０ｍｉｎ取静脉血测定，以ＭＣＰＫＰ药代动力学程序拟合药－时数据。结果表明，本药的处置符合房室开放模型。青年组与老年组比较，在Ｔ１／２Ｋａ、Ｔ１／２ｋ、Ｔｍａｘ、Ｃｍａｘ方面具有显著性差异（Ｐ＜０．０５）。在药效学方面的研究表明，随着血药浓度增高，ＭＡＰ、ＴＰＲ下降，ＨＲ、ＳＶ增高，血药浓度与各药效学指标相关性依次为ＭＡＰ＞ＨＲ＞ＳＶ＞ＴＰＲ。受试者两组间药效学指标波动范围ｔ检验ＭＡＰ、ＨＲ之间无显著性差异（Ｐ＞０．０５），ＳＶ、ＴＰＲ具有显著性差异（Ｐ＜０．０５）。
Pharmacokinetics of 16 healthy volunteer volunteers (8 in youth group and 8 in aged group) with single-dose sublingual nitroglycerin 0.5 mg were determined by gas chromatography-electron capture (GC-ECD) Pharmacodynamics were studied. Venous blood was taken before and after 2,4,6,7,8,10,15,20 min. The pharmacokinetics of MCPKP was used to fit the drug-time data. The results show that the disposal of the drug line with atrial opening model. There were significant differences in T1 / 2Ka, T1 / 2k, Tmax and Cmax between young group and elderly group (P <0.05). Pharmacodynamics studies have shown that with the increase of blood concentration, MAP, TPR decreased, HR, SV increased, plasma concentration and pharmacodynamic indicators were followed by MAP> HR> SV> TPR. There was no significant difference between the two groups (P> 0.05). SV, TPR had significant difference (P <0.05) between the two groups.