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应用造血祖细胞体外培养技术,观察了小鼠腹腔巨噬细胞对早期红系祖细胞(BFU-E)及晚期红系祖细胞(CFU-E)增殖的影响。结果表明,小鼠腹腔贴壁巨噬细胞对CFU-E表现为刺激作用;对BFU-E增殖依培养体系条件不同而表现为刺激和抑制双重作用。巨噬细胞培养上清液也表现相似的作用。提示巨噬细胞具有促红细胞生成素(EPO)和爆式集落促进活性(BPA)样活性。
The effect of mouse peritoneal macrophages on proliferation of early erythroid progenitor cells (BFU-E) and late erythroid progenitor cells (CFU-E) was observed using in vitro culture of hematopoietic progenitor cells. The results showed that the peritoneal adherent macrophages of mice showed a stimulatory effect on CFU-E. The proliferation of BFU-E showed a dual role of stimulation and inhibition depending on the culture system conditions. Macrophage cell culture supernatants also show similar effects. Tip macrophages have erythropoietin (EPO) and explosive colony-stimulating activity (BPA) -like activity.