PTEN——第10号染色体缺失的磷酸酶和张力蛋白同源物(phosphatase and tensin homolog located on chromosome ten)在各种人类癌症中发生突变,并利用其脂磷酸酶活性和蛋白磷酸酶等活性参与肿瘤细胞的细胞周期,转移和侵袭等过程。MicroRNAs(miRNAs)作为一类内源性单链非编码小分子RNA,能调控靶基因表达,研究发现,其与包括白血病,肺癌,肝癌等在内的几乎所有恶性肿瘤的发生发展紧密相关。近年研 PTEN, a phosphatase and tensin homolog located on chromosome ten, is mutated in a variety of human cancers and uses its activity of lipid phosphatase and protein phosphatase Cell cycle, metastasis and invasion of tumor cells. MicroRNAs (miRNAs), as a class of endogenous single-stranded non-coding small RNAs, can regulate the expression of target genes. The study found that microRNAs (miRNAs) are closely related to the development and progression of almost all malignant tumors including leukemia, lung cancer and liver cancer. In recent years research