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电喷雾萃取电离(EESI)技术是近年发展起来的一种可以在无需样品预处理的条件下对复杂基体样品进行直接质谱分析的新兴离子化技术.该技术能对液体、气溶胶、固体表面、黏性样品等不同形态样品进行分析.本文介绍了EESI技术的工作原理,系统阐述了EESI-MS技术在实际样品分析中的实现方式和技术特点,对EESI-MS现有的应用进行了简要的归纳和评述,展望了EESI技术在食品医药安全、公共安全、化学反应机理研究、代谢组学、蛋白质分析、临床诊断、环境监测等领域中的应用前景.
Electrospray ionization (EESI) technology is a new ionization technology developed in recent years that can directly mass spectrometry complex matrix samples without sample pretreatment.The technology can be liquid, aerosol, solid surface, Viscous samples, etc. The paper introduces the working principle of EESI technology, systematically expounds the implementation methods and technical features of EESI-MS in practical sample analysis, and gives a brief introduction of the existing application of EESI-MS Summarized and reviewed the prospect of EESI technology in the field of food and drug safety, public safety, mechanism of chemical reaction, metabolomics, protein analysis, clinical diagnosis and environmental monitoring.