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预给粉防己碱１５ｍｇ·ｋｇ￣（－１）每日２次连续３ｄ可以减轻大鼠工作心脏缺血再灌注心肌损伤；促进冠脉流出液，心输出量的恢复；防止左心室舒张末期压和等容舒张期左室内压下降时间常数的升高；抑制肌酸激酶释放；维持心肌线粒体Ｃａ￣（２＋）稳态。以上结果与硝苯地平关似。本研究表明粉防己碱对心肌缺血再灌注损伤具有较好的保护作用，以对心肌舒张功能及冠脉循环的保护为优。
Pretreatment of tetrandrine 15mg · kg ~ (-1) twice daily for 3 days can reduce myocardial ischemia and reperfusion myocardial injury in rats; to promote coronary effusion, cardiac output recovery; to prevent left ventricular end-diastolic pressure And diastolic left ventricular pressure constant pressure relaxation time constant increase; inhibition of creatine kinase release; maintain myocardial mitochondrial Ca ~ (2+) homeostasis. The above result is similar to nifedipine. This study shows that tetrandrine on myocardial ischemia-reperfusion injury has a good protective effect, to myocardial diastolic function and coronary circulation is the best protection.