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目的 :探讨咪唑安定在清醒镇静胃镜检查时最佳剂量 ,并观察其对呼吸循环的影响。方法 :36 0例胃镜检查患者 (ASAⅠ～Ⅱ级 ) ,随机分为对照组 ,咪唑安定 0 .0 4mg/kg组 ,咪唑安定 0 .0 6g/kg组 ,共 3组 ,观察其镇静分级并记录脑电图双频指数分析 (BIS值 )、检查过程的遗忘程度、检查后感受情况、循环MAP ,HR及指脉血氧饱和度 (SpO2 )的变化。结果 :0 .0 6mg/kg咪啶安定组用于胃镜检查是安全有效的 ,效果明显优于未用药组和0 .0 4mg/kg组 ,镇静程度明显 ,遗忘程度高 (P <0 .0 1) ,无任何后遗症 ,对呼吸循环功能影响较小。结论 :清醒镇静胃镜检查时咪唑安定以 0 .0 6mg/kg为最佳剂量
Objective: To investigate the optimal dose of midazolam during conscious sedation gastroscopy and observe its effects on respiratory circulation. Methods: Thirty-six patients with endoscopy (ASAⅠ ~ Ⅱ) were randomly divided into control group, midazolam 0. 04mg / kg group and midazolam 0. 06g / kg group. EIS bispectral index (BIS) was recorded. The degree of amnesia, the status of post-examination, circulatory MAP, HR and SpO2 were recorded. Results: 0. 0 6mg / kg midazolam group for gastroscopy is safe and effective, the effect was significantly better than the non-medication group and 0. 4mg / kg group, significant sedation, high degree of amnesia (P <0 .0 1), without any sequelae, less impact on respiratory function. Conclusion: Conscious sedation gastroscopy midazolam to 0. 6mg / kg as the best dose