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数种炎症疾病,包括哮喘、关节炎和银屑病等都与巨噬细胞、中性细胞和肥大细胞产生的白三烯(LT)有关。LT 生成的初级酶反应由脂肪氧合酶(5-LD)将花生四烯酸氧化到LT-A4上。用5-LD 转染的骨肉瘤细胞在破碎细胞悬液中表达酶活性,但加入钙离子亲和剂A23187进行刺激不能引起该细胞合成LT 产物,提示还有一种成分对于5-LD 活性是必需的,报道的一种新的吲哚LT 抑制剂(MK-886)能抑制细胞生成,但
Several inflammatory diseases, including asthma, arthritis and psoriasis, are associated with the production of leukotrienes (LTs) by macrophages, neutrophils, and mast cells. The primary enzymatic reaction generated by LT oxidizes arachidonic acid to LT-A4 by lipoxygenase (5-LD). Osteosarcoma cells transfected with 5-LD expressed enzymatic activity in the disrupted cell suspension but stimulation with calcium ionophile A23187 did not induce the cell to synthesize LT product, suggesting that another component is essential for 5-LD activity , A new indole LT inhibitor (MK-886) reported to inhibit cell formation but