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细胞表面唾液酸的功能各种各样;可延长红细胞、血小板及淋巴细胞的寿命;是粘病毒和副粘病毒的细胞受体部位;是红细胞血型抗元M、N的基本成分;其羟化的三碳节段又可结合细胞表面的Ca~(2+)。现提出,其带负电的羧基还可改变哺乳动物细胞的聚集能力。唾液酸对恶性变并无普遍作用。因为不同肿瘤细胞唾液酸浓度很不相同,某些正常细胞的唾液酸比转化细胞高。很多肿瘤细胞除去唾液酸后异体移植能力下降,但TA_3-Ha乳腺癌细胞除去唾液酸
Cell surface sialic acid has various functions; can extend the life span of erythrocytes, platelets and lymphocytes; is the cell receptor site of myxovirus and paramyxovirus; is the basic component of erythrocyte blood group anti-M, N; The three carbon segments can combine with the cell surface Ca ~ (2+). It is proposed that its negatively charged carboxyl groups also alter the aggregation ability of mammalian cells. Sialic acid has no universal effect on malignant transformation. Because of the very different concentrations of sialic acid in different tumor cells, some normal cells have higher sialic acid than transformed cells. Many tumor cells have reduced capacity for xenotransplating after removing sialic acid, but TA_3-Ha breast cancer cells remove sialic acid