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Shay和Sun提倡天秤说以来已近30年,这一观点今天仍在继承。近年研究工作主要在以下几方面:与胃酸和胃蛋白酶(侵袭因素)分泌有关的植物神经和消化道激素的动态、粘膜抵抗、粘液屏障、粘膜血流、十二指肠制动作用(duodenal brake)等防御因素本质的研究。尤其是关于胃粘膜防御机理的研究,可以说是有关溃疡病病因研究的世界性趋势。1980年3月在慕尼黑召开溃疡病发病机理和治疗的国际专题学术会,Grossman在总结时说:“今后消化性溃疡成因的研究方向就是把防御机理搞清楚。”他又说:“我确信,不久的将来粘膜防御这一论题必将占据我们绝大部份精力。”本文仅以他所强调的粘膜防御机理这一消化性溃疡的病因论为中心概述于下。
It has been almost 30 years since Shay and Sun advocated that Scales have been adopted. In recent years, the research work has been focused on the following aspects: dynamic changes of autonomic and gastrointestinal hormones related to gastric acid and pepsin (invasion factor) secretion, mucosal resistance, mucus barrier, mucosal blood flow, duodenal brake ) And other essential factors of defense research. In particular, the research on the mechanism of gastric mucosal defense can be said to be a worldwide trend in the study of the etiology of ulcer disease. Grossman, the international symposium on the pathogenesis and treatment of ulcer disease in March 1980 in Munich, concluded: “The research direction of the cause of peptic ulcer in the future is to clarify the defense mechanism.” He added: “I am sure, The topic of mucosal defenses in the near future is bound to dominate most of our energies. ”This article summarizes the etiology of the peptic ulcer, which he emphasizes, solely on the etiology of peptic ulcer disease.