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６－ＯＨＤＡ损毁大鼠一侧中脑黑质细胞造成偏侧帕金森病（ＰＤ）样大鼠模型，用小动物旋转行为记录仪记录阿朴吗啡诱发大鼠的旋转行为；ＴＨ免疫细胞化学染色观察中脑黑质细胞的损毁状况。连续观察１０个月其旋转行为无自发性恢复；ＰＤ样模型大鼠损毁侧中脑无ＴＨ阳性细胞存在。结果表明６－ＯＨＤＡ损毁大鼠一侧中脑黑质细胞可造成稳定、可靠的类似ＰＤ病人病理变化的偏侧动物模型。
6-OHDA damaged rat midbrain substantia nigra cells caused by Parkinson’s disease (PD) -like rat model, with a small animal rotation behavior recorder recording apomorphine-induced rat rotation behavior; TH immunocytochemical staining To observe the damage of midbrain substantia nigra cells. There was no spontaneous recovery after 10 months of continuous observation. TH-positive cells in the damaged midbrain of PD-like rats were found. The results show that 6-OHDA-lesioned rat mesencephalic substantia nigra can produce a stable and reliable hemipark animal model similar to the pathological changes of PD patients.