Chronically denervated distal nerve stump inhibits peripheral nerve regeneration

来源 :Neural Regeneration Research | 被引量 : 0次 | 上传用户:anxbbs
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Schwann cells(SCs)and peripheral nerve regeneration:SCs are the principal glial cells of the peripheral nervous system(PNS).In a healthy nerve,myelinating SCs wrap around larger caliber motor and sensory axons to form the myelin sheath,whereas non-myelinating SCs envelop and support multiple small diameter sensory axons to form Remak bundles.Moreover,they form a basal lamina which surround each SC-axon unit(Hall,2005).When a peripheral nerve injury occurs,extensive changes in Schwann cells (SCs) and peripheral nerve regeneration: SCs are the principal glial cells of the peripheral nervous system (PNS). In a healthy nerve, myelinating SCs wrap around larger caliber motor and sensory axons to form the myelin sheath, and non-myelinating SCs envelop and support multiple small diameter sensory axons to form Remak bundles. Moreover, they form a basal lamina that surround each SC-axon unit (Hall, 2005). W a peripheral nerve injury occurs, extensive changes in
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