论文部分内容阅读
近年来发现人和动物体内存在一种内源性洋地黄样物质,该物质对Na-K-ATP 酶能竞争抑制[~3H]-哇巴因与Na-K-ATP 酶的结合,能与地高辛抗体产生交叉结合反应。它具有利尿、排钠、强心和收缩血管等作用。该物质可能产生于下丘脑,高钠摄入和血容量扩张为其释放的有效刺激。内源性洋地黄样物质的性质和作用,与排钠激素、内源性钠泵抑制因子以及血管敏化因子等相似,可能是同一种或同一类物质。内源性洋地黄样物质参与高血压发病机理。
In recent years, it has been found that there is an endogenous digitalis-like substance in humans and animals that competes with Na-K-ATPase for inhibiting the binding of [~ 3H] -uvabaine to Na-K-ATPase, Digoxin antibodies produce cross-binding reactions. It has diuretic, sodium row, cardiac and systolic blood vessels and other effects. The substance may be produced in the hypothalamus, high sodium intake and blood volume expansion for its effective release of stimuli. The nature and role of endogenous digitalis-like substances, which may be the same or similar, are similar to those of sodium-releasing hormone, endogenous sodium-pump inhibitor and vascular sensitizing factor. Endogenous digitalis-like substances are involved in the pathogenesis of hypertension.