论文部分内容阅读
目的研究EGFR和PI3K表达的相关性,以及与进展期胃癌临床病理的关系。方法采用免疫组织化学法检测68例进展期胃癌组织EGFR和PI3K的表达情况,并分析其与胃癌临床病理的关系。结果 EGFR表达阳性率为58.82%(40/68),与淋巴结转移、远处转移及临床TNM分期有关(P<0.05);PI3K表达阳性率为76.47%(52/68),与肿瘤浸润深度、淋巴结转移、远处转移及临床TNM分期有关(P<0.05)。EGFR和PI3K共表达率为47.22%。结论 EGFR和PI3K在进展期胃癌组织中高表达,EGFR和PI3K的表达与胃癌的侵袭、转移密切相关,PI3K的表达与EGFR显著相关。
Objective To study the correlation between EGFR and PI3K expression and its relationship with clinical pathology of advanced gastric cancer. Methods Immunohistochemistry was used to detect the expression of EGFR and PI3K in 68 cases of advanced gastric cancer, and their relationship with clinicopathology of gastric cancer was analyzed. Results The positive rate of EGFR expression was 58.82% (40/68), which was related to lymph node metastasis, distant metastasis and clinical TNM staging (P<0.05). The positive rate of PI3K expression was 76.47% (52/68), and the depth of tumor invasion. Lymph node metastasis, distant metastasis and clinical TNM staging were related (P<0.05). The co-expression rate of EGFR and PI3K was 47.22%. Conclusion EGFR and PI3K are highly expressed in advanced gastric cancer tissues. The expression of EGFR and PI3K is closely related to the invasion and metastasis of gastric cancer. The expression of PI3K is significantly related to EGFR.