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目的探讨奥曲肽联合奥美拉唑治疗肝炎后肝硬化并上消化道出血的疗效。方法 84例肝硬化并上消化道出血患者,采用抽签法将其分为观察组与对照组,各42例。观察组患者行奥曲肽联合奥美拉唑治疗,对照组患者行垂体后叶素联合奥美拉唑治疗。观察两组患者的止血时间、治疗效果以及药物不良反应的发生情况。结果治疗后观察组的平均住院时间以及平均止血时间明显低于对照组,差异具有统计学意义(P<0.05);观察组的总有效率为97.6%明显高于对照组的83.3%,差异具有统计学意义(χ2=4.974,P<0.05);观察组总药物不良反应发生率为2.63%明显低于对照组的12.96%,差异具有统计学意义(χ2=5.126,P<0.05)。结论奥曲肽联合奥美拉唑治疗肝炎后肝硬化并上消化道出血具有更短的止血时间,更优的治疗效果以及更低的药物不良反应发生率,具有一定的临床意义。
Objective To investigate the efficacy of octreotide combined with omeprazole in the treatment of posthepatitic cirrhosis and upper gastrointestinal bleeding. Methods Eighty - four patients with cirrhosis and upper gastrointestinal bleeding were divided into the observation group and the control group by random sampling, 42 cases in each group. Patients in the observation group were treated with octreotide combined with omeprazole, and patients in the control group were treated with pituitrin combined with omeprazole. Two groups of patients were observed bleeding time, treatment and adverse drug reactions occurred. Results After treatment, the average length of stay and the mean time to stop bleeding in the observation group were significantly lower than those in the control group (P <0.05). The total effective rate in the observation group was 97.6%, which was significantly higher than that in the control group (83.3% Statistical significance (χ2 = 4.974, P <0.05). The incidence of adverse drug reactions in the observation group was significantly lower than that in the control group (2.63% vs 12.96%, χ2 = 5.126, P <0.05). Conclusion The combination of octreotide and omeprazole in the treatment of posthepatitic cirrhosis and upper gastrointestinal bleeding has a shorter bleeding time, better therapeutic effect and lower incidence of adverse drug reactions, and has certain clinical significance.