目的探讨酮替芬联合氯雷他定治疗小儿咳嗽变异性哮喘的临床疗效。方法 122例小儿咳嗽变异性哮喘患儿,随机分为对照组与实验组,各61例。实验组给予酮替芬联合氯雷他定治疗,对照组单纯给予酮替芬治疗,治疗2周后,观察比较两组的治疗效果及不良反应发生情况。结果实验组患儿的总有效率(95.08%)明显高于对照组(78.69%),差异具有统计学意义(P<0.05)。两组患儿不良反应发生率比较差异无统计学意义(P>0.05)。结论应用酮替芬联合氯雷他定治疗小儿咳嗽变异性哮喘取得了良好的临床效果,而且不良反应小,在临床中值得大力应用。 Objective To investigate the clinical efficacy of ketotifen and loratadine in the treatment of children with cough variant asthma. Methods A total of 122 children with cough variant asthma were randomly divided into control group and experimental group, with 61 cases in each group. The experimental group was treated with ketotifen plus loratadine, while the control group was given ketotifen alone. After two weeks of treatment, the therapeutic effect and adverse reactions of the two groups were observed and compared. Results The total effective rate (95.08%) in experimental group was significantly higher than that in control group (78.69%), the difference was statistically significant (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Ketotifen combined with loratadine treatment of pediatric cough variant asthma has achieved good clinical results, and adverse reactions, in the clinical application worthy of great.