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目的 :探讨幽门螺杆菌相关性胃窦炎症病理变化程度对血清、胃窦部粘膜组织中胃泌素水平的影响。方法 :对Hp阳性的活动性DU患者 30例、Hp阴性的活动性DU患者 1 0例、Hp阴性且病理表现仅有轻度浅表性胃炎的 1 0例正常对照患者进行内镜、胃粘膜组织学、幽门螺杆菌和血清、胃粘膜组织胃泌素水平检测 ,并分析其相互关系。结果 :幽门螺杆菌阳性患者血清、胃粘膜组织中胃泌素水平较幽门螺杆菌阴性患者显著升高 (P <0 0 1 )。胃窦组织中生长抑素水平明显降低 (P <0 0 1 )。结论 :幽门螺杆菌感染后胃泌素、生长抑素变化与DU的发生关系密切 ,并在疾病的发生发展中起一定作用。
Objective: To investigate the influence of pathological changes of Helicobacter pylori-associated gastric antral inflammation on the level of gastrin in serum and gastric mucosa. Methods: Thirty cases of Hp positive active DU, 10 cases of Hp negative active DU, 10 cases of Hp-negative and mild superficial gastritis were examined by endoscopy and gastric mucosa Histology, Helicobacter pylori and serum gastrin levels in gastric mucosa were measured and their correlations were analyzed. Results: Gastrin levels in serum and gastric mucosa of Helicobacter pylori positive patients were significantly higher than those in H. pylori negative patients (P <0.01). Somatostatin levels in gastric antrum significantly decreased (P <0.01). Conclusion: The changes of gastrin and somatostatin after Helicobacter pylori infection are closely related to the occurrence of DU, and play a role in the occurrence and development of the disease.