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本文以日本大耳白兔３４只分成输精管结扎组（ＶＧ）与假手术组（ＳＯＧ）。重点对比观察了两组血清睾酮水平与前列腺在术后６个月及２５月时形态学变化。结果：血清睾酮水平ＶＧ术后６月时降低；２５月恢复且略高于同期ＳＯＧ。前列腺组织学变化，６月组，ＶＧ较ＳＯＧ部分腺泡呈不同程度的萎缩，腺泡间结缔组织和平滑肌细胞增多。前列腺前叶的萎缩与睾酮水平下降相关。２５月组，ＳＯＧ前列腺前、后叶腺泡弥漫性萎缩，显示增龄性变化。ＶＧ的萎缩程度略轻于ＳＯＧ。各组均可见灶性鳞状上皮化生，但无统计学差异。各组前列腺前、后叶均未见明显上皮不典型增生，免疫组化染色ＰＣＮＡ及Ｐ５３均为阴性。证明输精管结扎术后较长期在前列腺前、后叶均未发生过度增生或癌前病变。
In this paper, 34 Japanese white rabbits were divided into vasectomy group (VG) and sham group (SOG). Focus on comparing the two groups of serum testosterone levels and prostate morphology at 6 months and 25 months after surgery. Results: The level of serum testosterone decreased at 6 months after VG, recovered at 25 months and slightly higher than that at the same period. Prostatic histological changes in June group, VG SOG part of the acinar showed varying degrees of atrophy, acinar connective tissue and smooth muscle cells increased. Atrophy of the anterior prostate gland is associated with decreased testosterone levels. In the 25-month group, diffuse atrophy of the anterior glandular and posterior glandular epithelium of the SOG showed age-related changes. The atrophy of VG is slightly lighter than that of SOG. Each group showed focal squamous metaplasia, but no statistical difference. No obvious epithelial atypical hyperplasia was found in the anterior and posterior lobes of each group. The PCNA and P53 were all negative in immunohistochemical staining. Proved vasectomy after a longer period in the prostate before and after the leaves were not hyperplasia or precancerous lesions.