Wnt-1诱导分泌蛋白3(WISP-3),是CCN家族成员之一,也称CCN6。它与大多数CCN家族成员的结构和功能相似,可编码多种细胞外基质蛋白,参与细胞的增殖分化与凋亡的调控,并可促进神经、血管、骨骼的发育。WISP-3表达水平的不同与多种恶性肿瘤的发生和发展有关,已成为CCN家族的研究热点之一。 Wnt-1 induces secretory protein 3 (WISP-3), a member of the CCN family, also known as CCN6. It is similar to the structure and function of most CCN family members and encodes a variety of extracellular matrix proteins that are involved in the regulation of cell proliferation and differentiation and apoptosis and promote the development of nerves, blood vessels and bones. The different WISP-3 expression levels have been associated with the occurrence and development of many malignant tumors and have become one of the research hotspots of CCN family.