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本文以大鼠应激性及幽门结扎法两种实验性胃溃疡为模型,就大黄及其炮制品以及不同用药方式对胃出血和出血灶的影响进行了实验观察比较。结果显示大黄及其炮制品对实验性胃溃疡的出血和出血灶的发生具良好的治疗和预防作用。作者认为其预防作用机制可能同甲氰咪胍相似,并可能同时对多种发病环节起作用。
In this paper, two experimental gastric ulcers of rat stress and pylorus ligation were used as models to observe the effects of rhubarb, its processed products and different methods of administration on gastric bleeding and hemorrhage. The results showed that rhubarb and its processed products have good therapeutic and preventive effects on the occurrence of experimental gastric ulcer bleeding and hemorrhage. The authors believe that its preventive mechanism may be similar to cimetidine, and may also act on a variety of pathogenesis.