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本文研究结果表明:PHA、SEB(葡萄球菌肠毒素B)、A23187、TPA均有不同程度诱导人胚胸腺细胞活化和增殖作用;TPA单独诱导作用较弱,但加入低浓度rHuIL-2可显著地促进其诱导增殖作用。而加入rHuIL-1则无促进作用;PHA和TPA间在诱导人胚胸腺细胞增殖中有很强的协同效应,而A23187对PHA诱导的增殖有明显的抑制作用,对TPA诱导的增殖有显著的促进作用。不同(20～36)周龄人胚胸腺细胞对上述刺激剂的反应结果基本一致。此结果对于了解人胚胸腺发育与胸腺细胞功能以及对于完善人胚胸腺细胞活化途径均有一定的意义。
The results of this study show that: PHA, SEB (Staphylococcal enterotoxin B), A23187, TPA have different degrees of induction of human embryonic thymocytes activation and proliferation; TPA alone induced weak, but the addition of low concentrations of rHuIL-2 significantly Promote its role in inducing proliferation. While the addition of rHuIL-1 did not promote; PHA and TPA in the induction of human embryonic thymocyte proliferation has a strong synergistic effect, while A23187 PHA induced proliferation was significantly inhibited TPA-induced proliferation was significantly enhancement. Different (20 ~ 36) weeks of human embryonic thymocytes response to the above stimuli results are basically the same. This result is of great significance for understanding the development of human embryonic thymus and the function of thymus cells and for improving the activation of human embryonic thymocytes.