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我们研制的流行性出血热(EHF)灭活疫苗,于1988年3月参加全国EHF灭活疫苗的统一考核。经中国药品生物制品检定所检定合格后,获得卫生部批准,进行了小批量的人体试验,现报告10例正常人接种后的反应和抗体产生情况如下。 1.疫苗:以EHF病毒Z10P10为毒种,感染沙鼠肾原代细胞,按流行性乙型脑炎的生物制品规程要求研制成的EHF灭活疫苗,并用β—丙内脂(含量为0.05%)代替甲醛溶液灭活病毒,于1988年1月24日制成。
We developed the epidemic hemorrhagic fever (EHF) inactivated vaccine, in March 1988 to participate in the national EHF inactivated vaccine unified assessment. After the Chinese pharmaceutical and biological products accredited by the test, obtained the approval of the Ministry of Health, conducted a small batch of human tests, 10 cases were reported normal response and antibody production after vaccination are as follows. 1. Vaccine: EHF virus Z10P10 as a kind of virus, infected with gerbil primary kidney cells, according to the requirements of biological encephalitis B EHF vaccine developed inactivated vaccine, and β-propiolactone (content of 0.05 %) Was used to inactivate the virus instead of formaldehyde solution and was made on January 24, 1988.