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Some novel dicoumarin derivatives, triethylene-glycol dibenzo[5,6] coumarin-3-carboxylate(1a),PEG (600) dibenzo[5,6]coumarin-3-carboxylate(1b), triethylene-glycol di[7-(N,N’-diethylamino)]-coumarin-3-carboxylate(2a), were synthesized. The cytotoxic effect of these compounds, along with benzo[5,6]coumarin-3-carboxylic acid(1) and 7-(N,N’-diethylamino)-coumarin-3-carboxylic acid(2), against the SGC-7901 cell lines were determined by Sulforhodamine B(SRB) assay. The preliminary cytotoxicity screening process revealed that the investigated dicoumarin derivatives induced 50% inhibition of the cell viability of SGC-7901 cells at micromolar concentrations. Compound 2a was proved superior to compound 1a according to the IC50 values obtained and the agent with PEG moiety has more contribution to cell-killing ability of the molecules than the remaining agents.
Some novel dicoumarin derivatives, triethylene-glycol dibenzo [5,6] coumarin-3-carboxylate (1a), PEG (600) dibenzo [5,6] The cytotoxic effect of these compounds, along with benzo [5,6] coumarin-3-carboxylic acid (1) and 7- (N, N’-diethylamino) The preliminary cytotoxicity screening process revealed that the investigated dicoumarin derivatives induced 50% inhibition of the SGC-7901 cell lines were determined by Sulforhodamine B (SRB) assay. The cell viability of SGC-7901 cells at micromolar concentrations. Compound 2a was proved superior to compound 1a according to the IC50 values obtained and the agent with PEG moiety has more contribution to cell-killing ability of the molecules than the remaining agents.