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脓毒症时补体激活,C_3和C_4降低,而血浆中它的分解代谢产物多肽(如过敏毒素等)增加,文献报道凡预后不良或有并发症(如休克或成人呼吸窘迫综合征)的病人,补体激活更为明显。本研究旨在评价脓毒症时补体激活程度是否与脓毒症的严重性相关。为此研究ICU中的26例病人,病人具备脓毒症6条标准中的4条:1)体温39℃或以上;2)寒战;3)心率>100次/分;4)呼吸急促(>30次/分);5)神智不清;6)白细胞增高(>10×10~9/升)。病人都经细菌学研究证实。肿瘤、慢性肝肾疾病或糖尿病除外,均不曾用过激素,全部病人均剖腹证实腹内感染灶,病人从收入ICU随访至出院或死亡。脓毒症严重评分(SSS)按Stevens法计算,急性生理学和慢性健康(APACHEH)评分按
Complement activation in sepsis, C_3 and C_4 decreased, and its plasma catabolism polypeptide (such as anaphylatoxins, etc.) increased, the literature reported that patients with poor prognosis or complications (such as shock or adult respiratory distress syndrome) patients , Complement activation is more obvious. The aim of this study was to evaluate whether the degree of complement activation in sepsis correlates with the severity of sepsis. For this purpose, 26 patients in the ICU were studied, and the patient had 4 of 6 criteria for sepsis: 1) body temperature 39 ° C or above; 2) chills; 3) heart rate> 100 beats / min; 4) 30 times / min); 5) confusion; 6) leukocytosis (> 10 × 10 ~ 9 / liter). Patients were confirmed by bacteriological studies. Excluding tumors, chronic liver and kidney disease or diabetes, none of the patients used hormones. All patients underwent abdominal dissection to verify their intra-abdominal infection, and patients were followed up from hospital discharge to hospital discharge or death. Severe sepsis score (SSS) According to the Stevens method, acute physiology and chronic health (APACHEH) score by