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目的 探讨血浆NT测定的意义及其临床价值。方法 研究对象分为正常对照组和胆囊结石病人组 ,正常对照组再分为五个年龄组。受试者空腹静脉取血两次 ,然后进行试验餐 ,餐后第 15min、30min、60min、12 0min各取血一次 ,分离血浆 ,采用放射免疫分析法测定血浆NT值。结果 67名正常人空腹血浆NT值 ,试验餐后明显升高 ,其血浆NT反应曲线出现两次高峰 ,2 0 -4 9岁组于餐后 15min出现最高峰 ,而 5 0岁以上组在餐后 30min出现最高峰 ,两者的峰水平差值相差非常显著。 2 3名胆石症患者空腹血浆NT值为 15 39± 1 94pmol/L ,试验餐后血浆NT值均显著大于基础水平 ,其血浆NT反应曲线与正常人 5 0岁以上组相似。正常人与胆石症患者血浆NT组比较 ,空腹及餐后各时间点血浆NT值均无显著差异 ,但有二分之一的病人餐后第二峰值显著大于对照组。结论 脂肪对神经细胞直接刺激是NT释放的重要因素和条件 ,但不是唯一的 ;神经系统可能参与调节引起餐后早期NT浓度升高的反应 ,血浆NT浓度升高可能是部分患者之胆石形成的重要因素。
Objective To investigate the significance of plasma NT and its clinical value. Methods The subjects were divided into normal control group and gallbladder calculi group. The normal control group was divided into five age groups. Subjects fasting venous blood twice, and then test meal, 15min, 30min, 60min after meal, 12min blood taken once, the plasma was separated by radioimmunoassay to measure plasma NT value. Results In 67 normal subjects, the fasting plasma NT value was significantly increased after the meal test. The plasma NT response curve peaked twice. The highest peak appeared in the 20-40 group at 15 min after meal, The peak appeared after 30min, the difference between the two peak levels is very significant. The fasting plasma NT was 15 39 ± 1 94 pmol / L in 23 patients with cholelithiasis. The postprandial plasma NT values were significantly higher than the baseline level, and the plasma NT response curve was similar to that of normal controls over 50 years old. There was no significant difference in plasma NT between normal subjects and patients with cholelithiasis plasma NT, but the second peak value after meal was significantly greater than that of the control group. Conclusions Direct stimulation of fat to nerve cells is an important factor and condition for NT release but not the only one; the nervous system may be involved in the regulation of the response that leads to an increase in early postprandial NT concentration. Increased plasma NT concentrations may be a form of gallstone in some patients Key factor.