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目的 探讨脑脊液肿瘤坏死因子 (TNF α)在儿童癫发病中的作用。方法 采用双抗体夹心法 ,检测 2 8例癫患儿发作期及间歇期脑脊液TNF α的含量。结果 癫患儿发作期及间歇期脑脊液TNF α含量均高于对照组 ,且发作期高于间歇期。结论 癫患儿发作期及间歇期脑脊液TNF α增高 ,在癫的发病中起重要作用
Objective To investigate the role of cerebrospinal fluid tumor necrosis factor (TNF α) in the pathogenesis of epilepsy in children. Methods Double antibody sandwich method was used to detect the contents of TNFα in cerebrospinal fluid during the onset and the intermittent period in 28 epileptic children. Results The levels of TNFα in cerebrospinal fluid in patients with epilepsy were significantly higher than those in control group during episode and intermittent periods, and the onset time was higher than intermittent. Conclusion Epilepsy in children with seizure and intermittent cerebrospinal fluid TNFα increased play an important role in the pathogenesis of epilepsy