22例患原发性实体性肿瘤肝转移已接受过化疗(4人还接受过白介素-2或干扰素),而对化疗呈抗药性的病人为治疗对象。局麻下经皮穿刺股动脉插管至肝动脉。通过加压泵,每天灌注重组人肿瘤坏死因子(rhTNF)12.5～175μg/m~2,连用5天,同时每24小时静滴肝累15000～20000U。每天监测部分促凝血酶原激酶时间(维持在高于基础值的50％～100％)第6天拔管。第28天开始第二疗程。以CT扫 Twenty-two patients with solid metastatic liver metastases had received chemotherapy (4 were also treated with interleukin-2 or interferon), and patients who were resistant to chemotherapy were treated. Under local anesthesia, the femoral artery was cannulated into the hepatic artery. Through a pressure pump, perfusion of recombinant human tumor necrosis factor (rhTNF) 12.5 ~ 175μg/m~2 per day, once every 5 days, while the hepatic instillation of 15,000 ~ 20000U every 24 hours. Daily monitoring of partial thromboplastin time (maintained at 50% to 100% above the baseline value) was extubated on day 6. The second course starts on the 28th day. Scan with CT