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[目的]探讨影响Ⅱ期胸段食管鳞癌术后预后的因素。[方法]回顾性分析南通市肿瘤医院胸外科2002年1月至2005年1月收治的296例单纯手术切除食管鳞癌患者的临床资料。[结果]全组总的1、3、5年生存率分别为86.8%(257/296)、54.0%(160/296)、42.9%(127/296)。ⅡA期和ⅡB期患者的5年生存率分别为51.3%(99/193)和27.2%(28/103)(P<0.001)。患者的性别、淋巴结转移、手术切缘情况、肿瘤浸润深度及组织分化程度均为预后影响因素(P<0.05),而患者年龄、肿瘤部位及肿瘤长度与预后无关(P>0.05)。[结论]影响Ⅱ期胸段食管鳞癌患者术后生存的主要因素有性别、淋巴结转移及手术切缘情况、肿瘤浸润深度及组织分化程度。
[Objective] To explore the factors influencing postoperative prognosis of stage Ⅱ thoracic esophageal squamous cell carcinoma. [Methods] The clinical data of 296 patients with simple esophageal squamous cell carcinoma who underwent surgical resection from January 2002 to January 2005 in Nantong Tumor Hospital were retrospectively analyzed. [Results] The overall 1, 3, 5-year overall survival rates were 86.8% (257/296), 54.0% (160/296) and 42.9% (127/296), respectively. The 5-year survival rates in patients with stage IIA and stage IIB were 51.3% (99/193) and 27.2% (28/103), respectively (P <0.001). The gender, lymph node metastasis, surgical margins, tumor infiltration depth and histological grade were the prognostic factors (P <0.05). However, age, tumor location and tumor length had no relation with prognosis (P> 0.05). [Conclusion] The main factors influencing postoperative survival in patients with stage Ⅱ thoracic esophageal squamous cell carcinoma are gender, lymph node metastasis and surgical margins, tumor invasion depth and degree of tissue differentiation.