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采用放射免疫学方法测定了26例婴幼儿肺炎血管紧张素Ⅱ(AⅡ)及心钠素(ANP)的浓度,并与30例正常健康小儿进行对照,发现肺炎时血浆AⅡ、ANP均高于正常儿,重症肺炎合并心衰时,其值更高。肺炎组的AⅡ与对照组之间有显著差异,t=3.84,P<0.01;肺炎组与对照组之间的ANP也有极显著的差异,t=5.68,P<0.01,表明AⅡ及ANP均参与肺炎的病理过程,其水平的高低与病情有关。可见,肺炎时检测AⅡ及ANP对判断心衰发生具有指导意义,并可结合临床提供应用扩管药治疗依据。
The concentrations of pneumonia A (Ⅱ) and atrial natriuretic peptide (ANP) in 26 infants and young children were determined by radioimmunoassay and compared with 30 normal healthy children. The levels of AⅡ and ANP in plasma were higher than those in normal children Children, severe pneumonia with heart failure, its value higher. There was a significant difference between AⅡ and control group in pneumonia group, t = 3.84, P <0.01. There was also a significant difference in ANP between pneumonia group and control group, t = 5.68, P <0.01, indicating that both AⅡand ANP were involved Pathological process of pneumonia, the level of the disease and the condition. Visible, pneumonia test A Ⅱ and ANP to determine the occurrence of heart failure has a guiding significance, and can be combined with the clinical application of expanding drug treatment basis.