近年来随着免疫组织化学技术的发展和研究的深入,肾上腺免疫组织化学标记物越来越受到学者的关注,主要涉及:组织发生来源的标记物;癌基因及抑癌基因蛋白;细胞周期、增殖与凋亡相关蛋白的调控;生长因子与受体活性的表达;端粒酶活性的异常增高;一些与细胞黏附和侵袭有关的特殊蛋白的表达;以及一些新发现的肿瘤相关特异性物质。这些标记物为肾上腺肿瘤临床病理诊断、基因治疗、估计预后提供了有力的参考依据。 In recent years, with the development of immunohistochemistry and further research, adrenal immunohistochemical markers have attracted more and more scholars’ attention, mainly related to: markers of tissue origin; oncogenes and tumor suppressor genes; cell cycle, Regulation of proliferation and apoptosis-related proteins; expression of growth factor and receptor activity; abnormal increase of telomerase activity; expression of specific proteins associated with cell adhesion and invasion; and some newly discovered tumor-associated specific substances. These markers for adrenal tumors clinical and pathological diagnosis, gene therapy, prognosis provides a powerful reference.