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目的探讨血塞通胶囊联合阿托伐他汀治疗脑梗死对颈动脉斑块稳定性及血脂水平的影响,总结其临床治疗经验。方法选择2013年5月至2015年5月脑梗死患者64例,随机分为治疗组与对照组,每组32例,治疗组采用血塞通胶囊联合阿托伐他汀治疗,对照组单纯采用阿托伐他汀治疗,观察对比两组治疗前和治疗12个月后彩超检测颈动脉内膜-中层厚度(IMT)、斑块类型及血脂相关指标的变化。结果两组患者治疗前彩超检测IMT组间比较,差异未见统计学意义(t=0.018,P>0.05),治疗12个月后组间比较,差异有统计学意义(t=-3.432,P<0.05)。治疗组治疗12个月后纤维型、脂质型组内比较,差异有统计学意义(P<0.05);脂质型组间比较,差异有统计学意义(P<0.05);对照组治疗12个月后所有类型与治疗前相比,差异未见统计学意义(P>0.05)。两组患者治疗前血脂相关指标比较,差异未见统计学意义(P>0.05),治疗12个月后组间比较,差异有统计学意义(P<0.05)。两组总急性脑血管事件发生率比较差异有统计学意义(P<0.05)。结论血塞通胶囊联合阿托伐他汀治疗脑梗死有利于促进颈动脉斑块的稳定,降低心脑血管事件发生,具有重要的临床意义。
Objective To investigate the effect of Xuesaitong capsule combined with atorvastatin on the stability of carotid artery plaque and blood lipid level in cerebral infarction and to summarize its clinical experience. Methods Sixty-four patients with cerebral infarction from May 2013 to May 2015 were randomly divided into treatment group and control group, with 32 cases in each group. The treatment group was treated with Xuesaitong capsule combined with atorvastatin. The control group was treated with A To observe and compare the changes of carotid intima-media thickness (IMT), plaque type and blood-lipid-related indexes before and 12 months after treatment in atorvastatin group. Results There was no significant difference between the two groups in the IMT group before treatment (t = 0.018, P> 0.05). After treatment for 12 months, the difference between the two groups was statistically significant (t = -3.432, P <0.05). There was significant difference between the treatment group and the control group (P <0.05). The difference between the two groups was statistically significant (P <0.05) There was no significant difference in all types between before and after treatment (P> 0.05). There was no significant difference between the two groups before treatment (P> 0.05). After 12 months of treatment, the difference between the two groups was statistically significant (P <0.05). There was significant difference between the two groups in the total incidence of acute cerebrovascular events (P <0.05). Conclusion Xuesaitong capsule combined with atorvastatin is effective in promoting the stability of carotid artery plaque and reducing the incidence of cardiovascular and cerebrovascular events, and has important clinical significance.