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目的检测结直肠癌组织中E-钙粘着蛋白(E-cadherin)、转化生长因子-β(transforming growth factorβ,TGF-β)和β-连环链蛋白(β-catenin)的表达,探讨3者之间的关系及其与临床病理特征间的联系。方法采用免疫组化方法分别检测56例结直肠癌标本癌和癌旁组织中E-cadherin、TGF-β、β-catenin的表达,并采用统计学方法分析其与肿瘤分化、浸润和转移之的相关性。结果癌组织中E-cadherin和β-catenin表达均低于癌旁组织(82.14%vs.100%,82.14%vs.89.29%,P<0.01),TGF-β表达癌组织高于癌旁组织(92.86%vs.75%,P<0.01),肿瘤恶性程度越高E-cadherin和β-catenin表达阳性率越低,呈负相关,相反,TGF-β表达与恶性程度呈正相关,均有统计学意义。结论结直肠癌标本癌和癌旁组织中3种蛋白E-cadherin、TGF-β、β-catenin的表达差异明显,并与肿瘤恶性程度呈正/负相关。
Objective To detect the expression of E-cadherin, transforming growth factor-β (TGF-β) and β-catenin in colorectal cancer tissues, Between the relationship and its clinical and pathological features of the link between. Methods The expressions of E-cadherin, TGF-β and β-catenin in 56 cases of colorectal cancer tissues and adjacent tissues were detected by immunohistochemistry. The expressions of E-cadherin, Correlation. Results The expressions of E-cadherin and β-catenin in cancer tissues were lower than those in adjacent non-cancerous tissues (82.14% vs.100%, 82.14% vs.89.29%, P <0.01) 92.86% vs.75%, P <0.01). The higher the degree of tumor malignancy, the lower the positive rate of E-cadherin andβ-catenin expression was, but negatively correlated. On the contrary, the expression of TGF-β was positively correlated with the degree of malignancy significance. Conclusion The expressions of E-cadherin, TGF-β, and β-catenin in colorectal cancer specimens and paracancerous tissues are significantly different from those in normal and paracancerous tissues.