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多发性硬化症(SEP)的慢性进展型现无有效疗法。动物实验高压氧有免疫抑制效应(Mertin 等,1984)及改善实验过敏性脑脊髓炎的进程(Prockop等,1978),因而曾被试用于临床,但大多数报道均无对照观察。Fisher 等1983年最初报告的随机安慰双盲对比研究认为治疗有效,而Barnes 等1985年的双盲法研究又未能证实有效。故作者们在两所医院中作进一步的双盲及安慰性治疗对比研究。52名患者自愿参加对照研究。能评价的49名病人符合Poser 等的SEP 诊断标准,缺陷低于或等于Kurtzke 量表的6级。病人均为慢性进行或稳定型。
Chronic progression of multiple sclerosis (SEP) is now no effective therapy. Animal experiments Hyperbaric oxygen with immunosuppressive effects (Mertin et al., 1984) and to improve the process of experimental allergic encephalomyelitis (Prockop et al., 1978), which has been tested for clinical use, but most reports were not controlled. The randomized, double-blind, placebo-controlled study reported first by Fisher et al. In 1983 found the treatment effective, and the double-blind study of Barnes et al., 1985, failed to prove effective. Therefore, the authors made further double-blind and soothing treatments in two hospitals. Fifty-two volunteers participated in the controlled study. The 49 eligible patients met the SEP diagnostic criteria of Poser et al., With defects less than or equal to grade 6 of the Kurtzke scale. Patients are chronic or stable type.