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醋炔诺酮丙酰肟在大鼠和小鼠妊娠1～5天口服的抗着床ED_(50)分别为0.068±0.02和0.31±0.1mg/kg,大鼠妊娠第2天单次肌注或口服的抗着床ED_(50)分别为0.53±0.1和3.5±0.7mg/kg。大鼠妊娠7～8天肌注5～10mg/kg醋炔诺酮丙酰肟有明显的终止早孕作用。醋炔诺酮丙酰肟在终止早孕剂量时,明显抑制假孕大鼠的蜕膜反应且使早孕大鼠的血清孕酮浓度明显下降。提示:醋炔诺酮丙酰肟的终止早孕作用可能与其抑制孕激素活性有关。
The norethindrone propionate propionate oxime in rats and mice 1 to 5 days of pregnancy oral ED50 (0.068 ± 0.02 and 0.31 ± 0.1mg / kg, respectively, a single intramuscular injection of gestation day 2 Or oral anti-implantation ED50 (50) were 0.53 ± 0.1 and 3.5 ± 0.7 mg / kg, respectively. Rats 7 to 8 days of gestation intramuscular injection of 5 ~ 10mg / kg acetylenic ketone propionyl oxime significantly termination of early pregnancy. Acetophenone propionate propionamid significantly inhibited the decidual response of pregnant rats and markedly decreased serum progesterone concentrations in premature pregnant rats at the termination of early pregnancy doses. Tip: Acetophenone propionate propionyl oxime termination of early pregnancy may be related to its inhibition of progesterone activity.