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ｐ16基因作为调控细胞周期的抑癌基因[1] ,在肺癌发生发展中起重要作用 ,其与Ｒｂ基因有可能共同构成肺癌基因分型诊断的基础[2 ] 。肺癌早期病理诊断一直是国内外医学界的难题 ,采用肺癌早期诊断立体定位仪[3] ,能为 1ｃｍ左右肺小病灶快速准确三维立体定位穿刺进行细胞病理诊
The p16 gene acts as an anti-oncogene for cell cycle regulation [1] and plays an important role in the development of lung cancer. It may together with the Rb gene form the basis for lung cancer genotyping diagnosis [2]. The early pathological diagnosis of lung cancer has always been a difficult problem in the medical community at home and abroad. The early diagnosis of lung cancer using stereotaxic apparatus[3] can provide rapid and accurate three-dimensional localization of lung lesions with 1cm or so of puncture for cytopathological diagnosis.