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急性上消化道出血偶尔可能威胁危重病人的生命。几乎所有危重病人均可能经内窥镜确定胃糜烂。虽然胃酸在急性胃糜烂的发病机制中起着关键作用,但粘膜的完整性极大地取决于粘膜渗透性、胃血流、牯膜分泌状况和酸硷平衡。影响生理过程的各种制剂,如维生素A、Carbenoxolone、胃泌素、舒血管制剂、碳酸氢钠和抗胆硷能制剂,已用于实验或临床以预防应激性溃疡。然而,尚缺乏临床对照研究。在对照前瞻性试验中,已证实制酸剂对防止危重病人的急
Acute upper gastrointestinal bleeding occasionally threatens critically ill patients. Almost all critically ill patients may be confirmed by endoscopy stomach erosion. Although gastric acid plays a pivotal role in the pathogenesis of acute gastric erosion, the integrity of the mucosa greatly depends on mucosal permeability, gastric blood flow, mucosal secretion status, and acid-base balance. Various agents that affect the physiological processes, such as vitamin A, Carbenoxolone, gastrin, vasodilators, sodium bicarbonate and anticholinergic agents have been used experimentally or clinically to prevent stress ulcers. However, there is a lack of clinical control studies. In a prospective trial, antacids have been shown to prevent critically ill patients