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目的:观察中药联合皮下胰岛素泵治疗初发2型糖尿病(气阴两虚型)对其证候积分及胰岛素抵抗的影响。方法:治疗组以中药联合皮下胰岛素泵治疗,对照组单予皮下胰岛素泵治疗。结果:治疗组患者治疗后临床症状体征有明显改善,有效率84.6%;对照组有效率74.9%。组间对比表明治疗组症状的改善明显优于对照组,有显著性差异(P<0.05)。治疗组患者治疗后空腹血糖、餐后2h血糖均明显降低,与治疗前比较均有显著性差异(P<0.01);与对照组比较亦有显著性差异(P<0.05)。治疗组FINS、ISI、HOMA-IR、HOMA-βcell较治疗前均有改善(P<0.05～0.01),与对照组比较有显著差异(P<0.05)。结论:中药联合皮下胰岛素泵治疗初发2型糖尿病(气阴两虚型),可明显提高疗效,改善胰岛素抵抗。
OBJECTIVE: To observe the effect of Chinese medicine combined with subcutaneous insulin pump on the treatment of newly diagnosed type 2 diabetes (Qi-Yin Deficiency) on its syndrome score and insulin resistance. Methods: The treatment group was treated with Chinese medicine combined with subcutaneous insulin pump, while the control group was treated with subcutaneous insulin pump alone. Results: After treatment, the symptoms and signs of the patients in the treatment group were significantly improved with an effective rate of 84.6% and the control group with an effective rate of 74.9%. Comparison between groups showed that the improvement of symptoms in treatment group was significantly better than that in control group, with significant difference (P <0.05). Fasting blood glucose and postprandial blood glucose at 2h after treatment in treatment group were significantly lower than those before treatment (P <0.01), and were significantly different from those in control group (P <0.05). The levels of FINS, ISI, HOMA-IR and HOMA-βcell in treatment group were significantly improved compared with those before treatment (P <0.05-0.01), which were significantly different from those in control group (P <0.05). Conclusion: Chinese medicine combined with subcutaneous insulin pump treatment of initial type 2 diabetes (Qi and Yin Deficiency), can significantly improve the efficacy and improve insulin resistance.