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INTRODUCTION Conceivably the presence of basement membrane(BM)in a neoplasm might be a result of interactionof tumor cells with the extracellular matrix.Collagen Ⅳ is one of the major intrinsic componentsof BM.Recent study has shown that collagen Ⅳhas cell adhesion function and is involved in theprocess of tumor invasion and metastasis,includingcolorectal cancer and breast cancer.But there arefew systematic studies on gastric cancer and theresults are equivocal.In this study we evaluated the
INTRODUCTION Conceivably the presence of basement membrane(BM)in a neoplasm might be a result of interactionof tumor cells with the extracellular matrix.Collagen IV is one of the major intrinsic components of BM.Recent study has shown that collagen IVhas cell adhesion function and is involved In the process of tumor invasion and metastasis, includingcolorectal cancer and breast cancer.But there arefew systematic studies on gastric cancer and theresults are equivocal.In this study we