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目的:探讨儿童急性白血病感染的临床特点及其相关性。方法:对2008年1月～2009年12月收治的98例儿童急性白血病患者的临床资料进行回顾性分析。结果:98例急性白血病儿童发生感染30例,感染率为30.6%。1～4岁组感染发生率与5～8岁组、9～13岁组比较差异有统计学意义(P<0.01);急性淋巴细胞白血病(ALL)感染发生率与急性非淋巴细胞白血病(ANLL)比较差异有统计学意义(P<0.05);WBC≤1.0×109/L感染发生率与WBC>1.0×109/L组相比差异有统计学意义(P<0.01);<10天组分别与10～30天组、>30天组比较差异有统计学意义(P<0.05)。结论:急性白血病儿童感染率高,主要是呼吸道感染,年龄、急性白血病类型、周围血白细胞、住院时间对感染发生率有显著影响。
Objective: To investigate the clinical features and the correlation of childhood acute leukemia infection. Methods: The clinical data of 98 children with acute leukemia admitted from January 2008 to December 2009 were analyzed retrospectively. Results: Thirty cases of 98 children with acute leukemia were infected with the infection rate of 30.6%. The incidence of infection in 1 to 4 years old group was significantly different from that in 5 to 8 years old group and 9 to 13 years old group (P <0.01). The incidence of acute lymphoblastic leukemia (ALL) was associated with acute non-lymphocytic leukemia (P <0.05). The incidence of WBC≤1.0 × 109 / L infection was significantly lower than that in WBC> 1.0 × 109 / L group (P <0.01) Compared with 10 ~ 30 days,> 30 days group, the difference was statistically significant (P <0.05). Conclusion: The infection rate of children with acute leukemia is high, mainly respiratory tract infection, age, type of acute leukemia, peripheral blood leukocytes and hospital stay have a significant impact on the incidence of infection.