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介绍了用气液色谱法定量测定氯醚避孕丸中的主要成份醋炔醚。氯地孕酮和赋形剂(苯甲酸苄酯、六氢吡啶和药用植物油)不干扰测定。在pH 2～3的氯仿溶液中,醋炔醚定量分解出环戊醇,以环已酮作内标进行测定,用峰高比计算。色谱条件:经酸洗的上试101白色担体(60～80目),涂渍20％聚乙二醇20M,氮为载气,柱温125℃,注样口200℃,用氢火焰离子化鉴定器。该法比较快速方便,制剂中醋炔醚测定的回收率为98.5～102％。
This paper introduces the quantitative determination of acetylene ether, the main ingredient in the chlorine-ether contraceptive pills, by gas-liquid chromatography. Chlordegestone and excipients (benzyl benzoate, piperidine and medicinal vegetable oils) do not interfere with the assay. In pH 2 ~ 3 chloroform solution, acetylene ether quantitative decomposition of cyclopentanol to cyclohexanone as an internal standard determination, calculated by the peak height ratio. Chromatographic conditions: pickled on the test 101 white support (60 to 80 mesh), coated with 20% polyethylene glycol 20M, nitrogen as a carrier gas, the column temperature of 125 ℃, injection port 200 ℃, flame ionization Verifier. The method is relatively quick and easy, the recovery of acetylene ether in the preparation was 98.5 ~ 102%.