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采用间接免疫荧光技术检测了未经治疗的Graves病患者和健康人外周血单核细胞膜上HLA-DR和HLA-DQ抗原的表达,并分析患者血清T_3、T_4、TSH水平与其单核细胞膜上HLA-DR和HLA-DQ抗原表达间的相关关系。结果表明:病人组HLA-DR~+和HLA-DQ~+单核细胞百分率(分别为57.42±8.73％和20.92±7.28％,±s)均显著低于正常对照组(分别为79.92±5.74％和40.33±6.34％,±s,P<0.001);患者血清TSH水平与其单核细胞膜上HLA-DQ抗原表达间存在显著正相关(r=0.687,P<0.05)。这些结果提示:Graves病患者体内存在单核细胞异常。
The expression of HLA-DR and HLA-DQ antigen in peripheral blood mononuclear cells of untreated patients with Graves disease and healthy people was detected by indirect immunofluorescence technique. The levels of T_3, T_4 and TSH in patients with Graves disease were compared with those in monocytes -DR and HLA-DQ antigen expression between the correlation. The results showed that the percentage of HLA-DR ~ + and HLA-DQ ~ + monocytes (57.42 ± 8.73% and 20.92 ± 7.28%, ± s, respectively) in patients were significantly lower than those in normal controls (79.92 ± 5.74% And 40.33 ± 6.34% respectively, ± s, P <0.001). There was a significant positive correlation between serum TSH level and the expression of HLA-DQ antigen on mononuclear cell membrane (r = 0.687, P <0.05). These results suggest that monocyte abnormalities exist in Graves’ disease.