Angew.Chem.Int.Ed.2014,53,4680~4684二氢吲哚[2,3]并杂环作为关键母核结构单元广泛存在于具有生理活性的天然产物以及手性药物分子中,发展简洁、高效的构建二氢吲哚[2,3]并杂环骨架的合成方法也受到了广泛的关注.其中,基于吲哚的催化不对称C(2),C(3)-分子内环化反应已经成为构建手性二氢吲哚[2,3]并杂环的最高效的方法之一.利用简便易得的吲哚衍生物与合成子发生分子间的C(2),C(3)-环化反应,虽然更加具有吸引力且更易于获得结构复杂多样的手性二氢吲哚[2,3]并杂环衍 Angew.Chem.Int.Ed.2014,53,4680 ~ 4684 Indoline [2,3] Heterocycles are widely found in natural physiologically active and chiral drug molecules as key core building blocks, with the development of Concise and efficient methods for the synthesis of indoline [2,3] and heterocyclic skeletons have also attracted a lot of attention, among which indole-based catalytic asymmetric C (2), C (3) The chemical reaction has become one of the most efficient methods for the construction of chiral indoline [2,3] and heterocycles.Using readily available indole derivatives and synthetic molecules to produce intermolecular C (2), C ( 3) -cyclization, although more attractive and easier to obtain complex and diverse chiral indoline [2,3] and heterocyclic derivatives