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【目的】观察支气管哮喘患儿全血锌、铁、钙、镁、铜、铅、锰、硒等微、常量元素含量的变化,并探讨其在支气管哮喘发病机制中的意义。【方法】采用原子吸收光谱法检测1 986例支气管哮喘患儿和856例正常对照组儿童全血锌、铁、钙、镁、铜、铅、锰、硒8种元素含量,并对检测结果作比较分析。【结果】支气管哮喘患儿组锌、铁和钙含量较正常对照组低,血铅含量较正常对照组高,两组间差异有统计学意义(P<0.05);而铜、镁、硒、锰两组间差异无统计学意义(P>0.05)。在哮喘的急性发作期,血锌、钙含量低于缓解期(P<0.05)。【结论】锌、铁、钙缺乏,铅暴露增加,是造成哮喘患儿免疫功能减低、免疫调节紊乱的重要原因,在治疗中需适当补充锌、铁、钙,减少铅暴露。
【Objective】 To observe the changes of trace elements and microelements in zinc, iron, calcium, magnesium, copper, lead, manganese and selenium in children with bronchial asthma and to explore its significance in the pathogenesis of bronchial asthma. 【Method】 The contents of zinc, iron, calcium, magnesium, copper, lead, manganese and selenium in whole blood of 1 986 children with bronchial asthma and 856 normal controls were detected by atomic absorption spectrometry. The test results comparative analysis. 【Results】 The levels of zinc, iron and calcium in children with bronchial asthma were lower than those in normal controls and blood lead levels were higher than those in normal controls (P <0.05). However, the levels of copper, magnesium, selenium, There was no significant difference between the two groups (P> 0.05). In acute exacerbation of asthma, blood zinc and calcium levels were lower than those in remission (P <0.05). 【Conclusion】 Lack of zinc, iron, calcium and lead exposure are the important reasons for the immunosuppression and immunomodulatory disorders in children with asthma. In the treatment, zinc, iron and calcium should be properly supplemented to reduce lead exposure.